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Related Experiment Videos

Mild cognitive impairment in the oldest old.

B Boeve1, J McCormick, G Smith

  • 1Department of Neurology, Mayo Alzheimer's Disease Research Center, Mayo Clinic, Rochester, MN 55905, USA. bboeve@mayo.edu

Neurology
|February 13, 2003
PubMed
Summary

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This study investigated amnestic mild cognitive impairment (MCI) in individuals aged 90-100. Findings show cognitive and functional performance patterns in this oldest-old group mirror those in younger populations.

Area of Science:

  • Gerontology
  • Neuroscience
  • Cognitive Aging

Background:

  • Limited data exists on amnestic mild cognitive impairment (MCI) in the oldest-old (90-100 years).
  • Previous findings on cognitive and functional status relationships may not apply to this extreme age group.

Purpose of the Study:

  • To determine if amnestic mild cognitive impairment (MCI) occurs in the oldest-old.
  • To examine if established relationships between functional status, neuropsychometric performance, and clinical diagnosis hold true in this population.

Main Methods:

  • Comprehensive neurologic evaluations, neuropsychometric testing, and functional assessments were conducted on 111 residents aged 90-100.
  • Subjects were classified as normal, amnestic mild cognitive impairment (MCI), or dementia using established criteria.

Related Experiment Videos

  • Data analyzed included Record of Independent Living (ROIL), Mini-Mental State Examination (MMSE), Dementia Rating Scale (DRS), Trailmaking Test (TMT), and Free and Cued Selective Reminding Test (FCSRT).

    • Main Results:

    • Functional capacity (ROIL) was lowest in dementia, but not significantly different between MCI and normal subjects.
    • Cognitive tests (MMSE, DRS, TMT-A) showed poorer performance in dementia compared to normal and MCI groups; no difference between normal and MCI.
    • Memory assessments (FCSRT, DRS memory subtest) revealed significant differences across all three groups (normal, MCI, dementia).

    Conclusions:

    • The relationship between cognitive function, functional performance, and clinical diagnosis in the oldest-old (90-100 years) aligns with patterns observed in younger individuals.
    • Amnestic mild cognitive impairment (MCI) is present in the oldest-old, and its cognitive and functional correlates are consistent with younger populations.