Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hemoglobin switching: new insights.

Kenneth R Peterson1

  • 1Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA. KPETERSON@kumc.edu

Current Opinion in Hematology
|February 13, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mitochondria Profoundly Influence Apolipoprotein E Biology.

Journal of Alzheimer's disease : JAD·2023
Same author

O-GlcNAcylation and O-GlcNAc Cycling Regulate Gene Transcription: Emerging Roles in Cancer.

Cancers·2021
Same author

NRF2 mediates γ-globin gene regulation through epigenetic modifications in a β-YAC transgenic mouse model.

Experimental biology and medicine (Maywood, N.J.)·2020
Same author

Episomal vectors based on S/MAR and the β-globin Replicator, encoding a synthetic transcriptional activator, mediate efficient γ-globin activation in haematopoietic cells.

Scientific reports·2019
Same author

An intergenic non-coding RNA promoter required for histone modifications in the human β-globin chromatin domain.

PloS one·2019
Same author

Conjugate prodrug AN-233 induces fetal hemoglobin expression in sickle erythroid progenitors and β-YAC transgenic mice.

Blood cells, molecules & diseases·2019
Same journal

Dynamic myeloid suppressor states in cancer and inflammation and their therapeutic potential.

Current opinion in hematology·2026
Same journal

Factor XIa inhibition for the prevention of thrombosis: mechanism, clinical trial signals, and indication-specific positioning.

Current opinion in hematology·2026
Same journal

Nutrition as a regulator of hematopoietic stem cell biology and transplantation.

Current opinion in hematology·2026
Same journal

From biomimicry to clinical actionability: rethinking high-shear thrombosis as a mechanobiological system.

Current opinion in hematology·2026
Same journal

Bidirectional relationship between metabolic and thrombotic disease mechanisms.

Current opinion in hematology·2026
Same journal

The dual role of the brain-derived neurotrophic factor as a regulator of hemostasis and thrombotic risk.

Current opinion in hematology·2026
See all related articles

Recent advances reveal how molecular mechanisms control beta-like globin gene switching. Transcription factors and chromatin structure interplay with regulatory elements to influence gene expression during development.

Area of Science:

  • Molecular Biology
  • Genetics
  • Developmental Biology

Background:

  • Beta-like globin gene switching is a crucial developmental process.
  • Understanding the molecular mechanisms is key to addressing related disorders.

Purpose of the Study:

  • To review recent advances in understanding beta-like globin gene switching.
  • To highlight the roles of regulatory elements, transcription factors, and chromatin structure.

Main Methods:

  • Review of recent scientific literature.
  • Analysis of molecular mechanisms controlling gene expression.
  • Characterization of protein-DNA interactions and chromatin modifications.

Main Results:

  • Identification of cis-acting elements dynamically bound by trans-acting proteins.

Related Experiment Videos

  • Elucidation of transcription factor interactions and their impact on gene regulation.
  • Increased understanding of chromatin structure's role in globin gene expression.

    • Conclusions:

    • Globin gene switching involves a complex interplay between cis-acting elements, transcription factors, and chromatin modifiers.
    • These molecular interactions are critical for developmental gene regulation.