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Related Experiment Videos

Left ventricular reshaping: effects on the pressure-volume relationship.

Abul Kashem1, Sarmina Hassan, Deborah L Crabbe

  • 1Cardiovascular Research, Temple University, Philadelphia, PA 19140, USA. mkashem@temple.edu

The Journal of Thoracic and Cardiovascular Surgery
|February 13, 2003
PubMed
Summary

The CardioClasp device reshaped the left ventricle, reducing wall stress and improving contractility in dogs with heart failure. This innovative device shows potential for clinical application in patients with heart failure.

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Area of Science:

  • Cardiovascular Research
  • Biomedical Engineering
  • Medical Devices

Background:

  • Heart failure is a significant clinical challenge characterized by impaired left ventricular function.
  • Current treatments aim to manage symptoms and slow disease progression, but novel therapeutic approaches are needed.
  • The CardioClasp device represents a new strategy to mechanically support and reshape the failing left ventricle.

Purpose of the Study:

  • To evaluate the efficacy of the CardioClasp device in improving left ventricular contractility.
  • To assess the device's impact on left ventricular wall stress and dimensions.
  • To determine if the CardioClasp device can enhance global left ventricular performance in a heart failure model.

Main Methods:

  • Severe heart failure was induced in dogs (n=6) via ventricular pacing.

Related Experiment Videos

  • The CardioClasp device, a non-blood contact device with indenting bars, was implanted to reshape the left ventricle.
  • Hemodynamics, echocardiography, and ventricular dimensions were measured before and after device placement.

    • Main Results:

    • The CardioClasp device significantly reduced left ventricular wall stress (P=.003) and end-diastolic dimensions.
    • Fractional area of contraction increased significantly (P=.002), indicating improved contractility.
    • Key indices of global left ventricular contractility, including end-systolic pressure-volume relationship slope, increased significantly (P=.01 to P=.02).

    Conclusions:

    • The CardioClasp device effectively reshaped the left ventricle, decreasing wall stress and enhancing fractional area of contraction.
    • The device maintained cardiac output and arterial pressure while improving global left ventricular contractility.
    • These findings suggest the CardioClasp device holds promise for clinical application in managing heart failure.