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Preoperative combination chemotherapy with S-1 and low dose cisplatin against highly advanced gastric carcinoma
Yoshiro Saikawa1, Yoshikiyo Akasaka, Toshio Kanai
1Department of Surgery, School of Medicine, Keio University, Tokyo 160-8582, Japan. saiky@sc.itc.keio.ac.jp
Abstract:
We performed preoperative chemotherapy with S-1 and low-dose CDDP (TSLD) to treat 9 patients of highly advanced gastric cancer. Five cases showed significant effect with severe fibrosis diagnosed as grade 1b-2 effect in histology, and all 9 cases showed at least grade 1a effect in either primary lesion or lymph node. While toxicity of less than grade 3 (gastrointestinal disorder and/or bone marrow suppression) were observed in 5 out of 9 cases (55.6%), no symptom was observed in 3 out of the 5 patients. We conclude that the TSLD is useful to control highly advanced gastric cancer.
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