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[Association of coagulation factor V, VII gene polymorphisms with coronary heart disease]
Geng Xu1, Guo-dong Jin, Guo-sheng Fu
1Department of Cardiology, the Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, PR China.
Insights
The Q allele of the FVII gene R353Q polymorphism may protect against myocardial infarction. This study investigated coagulation factor gene polymorphisms in the Chinese Han population and their link to coronary heart disease.
Area of Science:
- Genetics
- Cardiovascular Disease Research
- Population Genetics
Context:
- Coronary heart disease (CHD) is a significant global health concern.
- Genetic factors play a crucial role in CHD susceptibility.
- Understanding gene polymorphisms associated with CHD is vital for risk assessment.
Purpose:
- To determine the distribution of coagulation factor V (FV) and factor VII (FVII) gene polymorphisms in the Chinese Han population.
- To investigate the association between these polymorphisms and the risk of developing coronary heart disease (CHD).
Summary:
- Genotyping of FV and FVII gene polymorphisms was performed in 234 CHD patients and 210 controls using PCR-RFLP.
- No significant differences in allele or genotype frequencies for R353Q or HVR4 polymorphisms were found between the overall CHD and control groups.
- A significant difference in R353Q allele and genotype distribution was observed between non-myocardial infarction and myocardial infarction subgroups, suggesting a protective role for the Q allele against myocardial infarction.
Impact:
- The findings suggest that the Q allele of the FVII R353Q polymorphism may confer protection against myocardial infarction in the studied population.
- This research contributes to the understanding of genetic risk factors for CHD.
- Further studies could explore the mechanisms underlying this protective effect and its clinical implications.
Objective:
To study the distribution of coagulation factor V(FV), VII(FVII) gene polymorphisms in Chinese Han population and the association of the polymorphisms with coronary heart disease(CHD).
Methods:
Genotypes of FV FVII were typed in 234 CHD patients and 210 controls by polymerase chain reaction-restriction fragment length polymorphism. Selected coronary angiography was performed in 234 CHD patients.
Results:
FVII allelic frequencies of R,Q and H7,H6 were 94.6%, 5.6%, 70.3%, 29.7% and 91.9%, 8.1%, 60.9%, 39.1% in CHD group and control group respectively. Genotype distribution was in accordance with Hardy-Weinberg equilibrium. There was no significant difference in frequencies of allele and genotype in R353Q or HVR4 polymorphisms between CHD group and control group. The distribution of allele and genotype in R353Q was of significant difference between non-myocardial infarction subgroup and myocardial infarction subgroup (chi2 = 4.711, P<0.05, OR=0.37,95% CI: 0.15-0.94). However, HVR4 polymorphism was not found to be of significant difference within two group (chi2 = 0.142, P>0.05). There was no FV Leiden mutation in all the CHD patients and normal controls.
Conclusion:
The Q allele of the R353Q polymorphism of the FVII gene may be a protective factor against myocardial infarction.