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[Apolipoprotein E genotypes and carotid artery atherosclerosis in type 2 diabetes mellitus]
Guang-da Xiang1, Tai-hong Hu, Yun-lin Wang
1Department of Endocrinology, Wuhan General Hospital of PLA, Wuhan, Hubei, PR China. Guangda64@163.net
Objective:
To investigate the relationship between carotid artery intima media thickness (IMT) and apolipoprotein (Apo) E gene polymorphisms in type 2 diabetes mellitus (DM2).
Methods:
Two hundred and fifty-five DM2 patients without angiopathy and 107 healthy individuals were selected. PCR/allele-specific oligonucleotide probe was used to determine their apoE genotypes.
Results:
The prevalence distribution of apoE genotypes and alleles in DM2 patients and that in controls were similar. The TC, LDL-C and Lp(a) concentrations in e4/4, e4/3 subgroups were significantly higher than those in e3/2, e2/2 subgroups (P<0.05). The average value of IMT in e4/4 e4/3 carriers (0.89 mm) was significantly greater than that in e3/2 e2/2 carriers (0.62 mm) (P<0.05). After adjustment for TC, LDL-C, TG, Lp(a), FBG, HbA1c, age, BMI, and smoking, ANCOVA showed that the average value of carotid IMT was significantly greater in subjects with e4/4 e4/3, compared with that in subjects with e3/2 e2/2(P=0.033).
Conclusion:
Apo e4 allele increases the risk for carotid artery atherosclerosis in the early stage of diabetic population.