Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Associations between six functional genes and schizophrenia].

Ming-lian Zhang1, Guo-zhen Yuan, Jian-jun Yao

  • 1The Seventh People Hospital of Wuxi City, Wuxi, Jiangsu, PR China. Yjj-wx@sina.com

Zhonghua Yi Xue Yi Chuan Xue Za Zhi = Zhonghua Yixue Yichuanxue Zazhi = Chinese Journal of Medical Genetics
|February 13, 2003
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Retraction notice to "Ultra-sensitive detection of melanoma NRAS mutant ctDNA based on programmable endonucleases" [Cancer Genetics 294-295 (2025) 47-56].

Cancer genetics·2026
Same author

Efficacy and safety of Tuina therapy for children with combined allergic rhinitis and asthma syndrome in remission: a randomized controlled trial protocol.

Frontiers in medicine·2026
Same author

Flame-Retardant Quasi-Solid-State Electrolytes From Self-Assembled Azolate Hybrid Frameworks for Highly Safe Lithium Batteries.

Angewandte Chemie (International ed. in English)·2026
Same author

Influence Mechanism of PA on the Thermal Decomposition of RDX Based on ReaxFF MD and DFT.

Molecules (Basel, Switzerland)·2026
Same author

Patchouli alcohol triggers autophagic cell death in non-small cell lung cancer cells through targeting GNAI1 to dissociate the GNAI1/ARRB1 complex.

International journal of biological sciences·2026
Same author

Detrimental impacts of ammonia exposure during marine heatwaves on the starry flounder (Platichthys stellatus).

Journal of environmental sciences (China)·2026

The dopamine transporter gene (DAT1) 480 bp allele is negatively associated with schizophrenia in the Chinese Han population. This finding supports the dopamine hypothesis of schizophrenia.

Area of Science:

  • Neurogenetics
  • Psychiatric Genetics

Context:

  • Schizophrenia is a complex psychiatric disorder with a significant genetic component.
  • Dopamine system dysregulation is a key hypothesis in schizophrenia pathophysiology.
  • Investigating specific gene variants offers insights into genetic risk factors.

Purpose:

  • To examine the association between schizophrenia and six candidate functional genes.
  • Specifically, dopamine D2 receptor (DRD2), dopamine D4 receptor (DRD4), 5-HT2A, 5-HT6, COMT, and DAT1 genes were analyzed.
  • To determine if specific alleles or genotypes correlate with schizophrenia in a Chinese Han population.

Summary:

  • Association analysis was performed on 67 schizophrenic patients and controls using Amp-RFLP and Amp-FLP.
  • No significant differences were found for DRD2, 5-HT2A, 5-HT6, and COMT genes.

Related Experiment Videos

  • Significant differences were observed for the DRD4 six repeats (6R) and DAT1 480 bp allele/480/520 genotype.
  • A negative association was identified between the DAT1 480 bp allele and schizophrenia (OR=0.441).

    • Impact:

    • The 480 bp allele of the DAT1 gene may confer a protective effect against schizophrenia in the studied population.
    • This finding provides genetic evidence supporting the dopamine hypothesis of schizophrenia.
    • Highlights the importance of DAT1 in schizophrenia etiology and potential therapeutic targets.