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[Study on the release mechanism of fenoprofen calcium from hydrophillic sustained-release matrix]
1Department of Pharmaceutics, Shenyang Pharmaceutical University, Shenyang 110015, China. zhaocs@hotmail.com
Aim:
To study the release mechanism of fenoprofen calcium (FC) from hydroxypropylmethylcellulose (HPMC) matrices.
Methods:
The release of FC and the erosion properties of hydrophillic matrices containing HPMC was examined at different paddle speed. The release mechanism of FC was further confirmed by evaluating the n value in Peppas equation.
Results:
The results indicate that the release of FC and the erosion of matrices exhibit zero order kinetic equation, and it exhibits line relationship between them.
Conclusion:
In the first 40 min, FC mainly released by diffusion and erosion from HPMC matrix, while it was controlled by the rate of tablet erosion after 50 min.