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Updated: Sep 27, 2026
Rodent Working Heart Model for the Study of Myocardial Performance and Oxygen Consumption
Published on: August 16, 2016
[Cardiac-hemodynamic effects of M3 receptor agonist on rat and rabbit hearts]
Aim:
To study the activation of choline on M3-R in heart and observe the hemodynamic changes of rat and rabbit.
Methods:
A cardiac catheter was inserted into the left ventricular cavity via the right carotid artery, then the HR, LVSP, LVEDP, and +/- dp/dt were measured using a polygraph system.
Results:
Choline was shown to decrease the hemodynamic assessments, such as HR, + dp/dt, LVSP and LVEDP. while the M3-R antagonist 4-DAMP (4-diphenylacetoxy-N-methylpiperidine-methiodide) showed little effect on these assessments. It was found to reverse the hemodynamic effects of choline.
Conclusion:
M3 receptor agonist can produce negative inotropic and chronotropic effects on the heart of rat and rabbit.
