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[Synthesis and biological activity of 2-[(substituted phenyl)vinyl] indole derivatives]
1Institute of Materia Medica, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100050, China.
Yao Xue Xue Bao = Acta Pharmaceutica Sinica
|February 13, 2003
Abstract
Aim:
To synthesize derivatives of 2-[substituted phenyl)vinyl] indole and find compounds with biological activities by screening in vitro.
Methods:
Twenty-one compounds of 2-[(substituted phenyl) vinyl] indole were synthesized by reduction, oxidation and Witting reaction. MS, 1HNMR and elemental analysis were used to determine the structures of the new compounds.
Results:
These compounds are new ones.
Conclusion:
Six compounds (3, 9, 11, 13, 18 and 20) showed effects on some different receptors, such as alpha 2, D2 and H1, and is worth further studying.