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[Study of sesquiterpene alkaloids from Tripterygium wilfordii Hook.f]
Yao Xue Xue Bao = Acta Pharmaceutica Sinica
|February 13, 2003
Abstract
Aim:
To study the chemical composition of Tripterygium wilfordii Hook.f.
Methods:
Column chromatography was used to separate the chemical constituents. UV, IR, MS, HRMS, 1HNMR, 13CNMR (COM and OFR), 1H-1H COSY, 1H-13C COSY, 2D-NOESY and 1H-13C COLOC were used to determine the structures of the isolated constituents.
Results:
Two sesquiterpene alkaloids were isolated and their structures were elucidated as euonine and wilfordconine on the basis of spectral evidence.
Conclusion:
Wilfordconine, a new sesquiterpene alkaloid, was shown to be immunosuppressive.