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Related Experiment Videos

[Transdermal microparticle delivery by a supersonic-Helios gun system].

Y Jin1, M Uchida, C F Wang

  • 1College of Pharmacy, Zhejiang University, Hangzhou 310031, China. jinyizhz@mail.hz.zj.cn

Yao Xue Xue Bao = Acta Pharmaceutica Sinica
|February 13, 2003
PubMed
Summary

High-speed helium gas delivery enhances indomethacin absorption through skin using microspheres. This needle-less system shows potential for effective drug and microparticle delivery into systemic circulation.

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Area of Science:

  • Pharmacology
  • Biomaterials Science
  • Drug Delivery Systems

Background:

  • Systemic drug absorption is crucial for therapeutic efficacy.
  • Conventional drug delivery methods face challenges in efficient systemic uptake.
  • Needle-less injection systems offer a promising alternative for transdermal drug delivery.

Purpose of the Study:

  • To evaluate the impact of particle size and helium gas velocity on indomethacin systemic absorption.
  • To assess the efficacy of a novel needle-less injection system for transdermal drug delivery.
  • To investigate the influence of supersonic helium flow on drug bioavailability.

Main Methods:

  • Poly-L-lactic acid microspheres loaded with indomethacin were fabricated using the o/w solvent evaporation technique.

Related Experiment Videos

  • A Helios gun system utilized helium gas streams at varying velocities to accelerate microspheres.
  • Microspheres were delivered transdermally to the abdominal skin of anesthetized hairless rats.

    • Main Results:

    • Indomethacin delivery into the skin increased proportionally with helium gas pressure (supersonic flow).
    • Systemic bioavailability and maximum concentration (Cmax) of indomethacin were dependent on helium pressure.
    • The study demonstrated a correlation between gas velocity and drug absorption.

    Conclusions:

    • The needle-less injection system effectively delivers powdered drugs and microparticulate systems.
    • This technology facilitates drug penetration into skin tissues and subsequent systemic circulation.
    • Supersonic helium gas flow is a key factor in enhancing transdermal drug absorption.