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[Terbium sensitized chemiluminescence of enoxacin]
Yao Xue Xue Bao = Acta Pharmaceutica Sinica
|February 13, 2003
Abstract
Aim:
To determine the enoxacin by means of terbium sensitized chemiluminescence in pharmaceutical preparations as well as urine samples.
Methods:
Through six-way injection valve Ce4+, H2SO3, Tb3+ and enoxacin (ENX) standard solutions were injected into the flow system in a certain order, the chemiluminescence signal was detected by weak luminescence analyzer.
Results:
The chemiluminescence intensity was linearly related to the concentration of ENX in the range of 2.0 x 10(-9)-6.0 x 10(-8) mol.L-1 with a detection limit of 4.0 x 10(-10) mol.L-1. Relative standard deviation was less than 1.6% (n = 11).
Conclusion:
It provides a sensitive rapid, simple and accuracy measurement of enoxacin for the pharmacokinetic studies.