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Updated: Jul 11, 2026
Crystallization of Membrane Proteins in Lipidic Mesophases
Published on: March 28, 2011
[Study on water of crystallization in tazobactam]
Yao-zuo Yuan1, Chang-qin Hu, Shao-hong Jin
1Jiangsu Province Institute of Drug Control, Nanjing 210008, China.
Aim:
To investigate whether tazobctam has crystallization water.
Methods:
In order to establish a method for water content determination in tazobctam, many methods including Karl Fischer titration, weight loss on drying, TGA, DSC and X-ray diffraction experiment of an orthorhombic form were studied.
Results:
The water content of the same batch tazobactam determined by different mthods was different.
Conclusion:
The results showed that one mole tazobatam contains half mole water of crystallization and the strength of attraction between tazobatam molecule and water molecule is rather strong.
