Related Experiment Video
Updated: Aug 3, 2026
06:56
1,3,5-Triphenylbenzene and Corannulene as Electron Receptors for Lithium Solvated Electron Solutions
Published on: October 10, 2016
[Studies on the stability of ligustilide with solvent effect]
1Department of Chemistry, Zhejiang University, Hangzhou 310027, China. cxzhou@css.zju.edu.cn
Yao Xue Xue Bao = Acta Pharmaceutica Sinica
|February 13, 2003
Summary
Ligustilide is significantly more stable in organic solvents like cyclohexane and chloroform compared to air. Storing ligustilide in these solvents effectively prevents its isomerization, enhancing its preservation.
Area of Science:
- Computational chemistry
- Physical organic chemistry
Context:
- Ligustilide, a key compound, exhibits instability.
- Understanding solvent effects is crucial for chemical preservation.
Purpose:
- To investigate the impact of solvent effects on ligustilide stability.
- To establish a preservation method for ligustilide.
Summary:
- Quantum chemistry calculations using the PCM solvent model were employed.
- Gas chromatography-mass spectrometry (GC/MS) analyzed ligustilide stability in solvents.
- Ligustilide isomerization decreased from 58% in air to 1.6% in cyclohexane and 6.7% in chloroform.
Impact:
- Demonstrates that solvent effects significantly enhance ligustilide stability.
- Proposes using appropriate organic solvents as an effective preservation strategy for ligustilide.
Related Concept Videos
03:24Common Ion Effect
Compared with pure water, the solubility of an ionic compound is less in aqueous solutions containing a common ion (one also produced by dissolution of the ionic compound). This is an example of a phenomenon known as the common ion effect, which is a consequence of the law of mass action that may be explained using Le Châtelier’s principle. Consider the dissolution of silver iodide:
02:18The Equilibrium Binding Constant and Binding Strength
The equilibrium binding constant (Kb) quantifies the strength of a protein-ligand interaction. Kb can be calculated as follows when the reaction is at equilibrium:
02:12Solvating Effects
An understanding of the solvating effect helps rationalize the relation between solvation and acidity of the compound. In addition, this also explains the relative stability of conjugate bases for compounds with different pKa values. This lesson details, in-depth, the principle of solvating effects. The strength of an acid and the stability of its corresponding conjugate base are determined using pKa values. This observed relationship is a consequence of solvation, which is the interaction...
01:15Theories of Dissolution: Diffusion Layer Model
Dissolution, the process by which drug particles dissolve in a solvent, is explained by the diffusion layer model, a theoretical framework that simulates the absorption of oral drugs and allows us to analyze experimental data.
This process starts with a thin layer, saturated with the drug, forming at the interface between the solid and liquid. The solute then diffuses from this layer into the main solution. The Noyes-Whitney equation suggests that the rate of dissolution relies on the diffusion...
This process starts with a thin layer, saturated with the drug, forming at the interface between the solid and liquid. The solute then diffuses from this layer into the main solution. The Noyes-Whitney equation suggests that the rate of dissolution relies on the diffusion...
01:20Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry
Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
01:16Drug Product Stability
The long-term stability of drug products is critical to ensuring their quality, safety, and effectiveness over time. Stability directly influences a product's ability to maintain its intended characteristics, ensuring it performs as expected during its intended shelf life. Key attributes such as drug potency, impurities, dissolution, and other physicochemical measures of performance are tested to assess stability. These parameters indicate how well the product retains its quality over time and...