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12:24
Murine Model of CD40-activation of B cells
Published on: March 6, 2010
B-cell lymphomas with coexpression of CD5 and CD10
Henry Y Dong1, Wojciech Gorczyca, Zach Liu
1IMPATH Inc, 521W 57th St, 6th Floor, New York, NY 10019, USA.
American Journal of Clinical Pathology
|February 13, 2003
Summary
Coexpression of CD5 and CD10 in B-cell lymphomas is rare, occurring in diverse subtypes. Investigating markers like bcl-1, bcl-6, and CD43 aids accurate diagnosis and subtype identification.
Area of Science:
- Hematology
- Oncology
- Immunopathology
Background:
- Coexpression of CD5 and CD10 is uncommon in B-cell lymphomas, presenting diagnostic challenges.
- This dual marker expression is observed in approximately 0.4% of all B-cell lymphomas.
Purpose of the Study:
- To investigate the spectrum of B-cell lymphoma subtypes exhibiting simultaneous CD5 and CD10 expression.
- To identify key diagnostic markers and assess prognostic implications in these rare lymphomas.
Main Methods:
- Retrospective analysis of 42 B-cell lymphoma cases with CD5 and CD10 coexpression.
- Morphological evaluation, immunohistochemistry for CD43, bcl-1, bcl-6, and cytogenetic analysis for t(11;14).
Main Results:
- The cohort included large B-cell lymphoma (LBCL, 33%), follicular lymphoma (FL, 24%), mantle cell lymphoma (MCL, 21%), chronic lymphocytic leukemia (10%), and others.
- Mantle cell lymphomas were CD43+ with bcl-1 overexpression or t(11;14). Follicular lymphomas were CD43- and bcl-2+, bcl-6+.
- Large B-cell lymphomas showed a poor prognosis, with 43% mortality within 10 months, particularly in advanced stages or high-grade histology.
Conclusions:
- Coexpression of CD5 and CD10, though rare, occurs across various B-cell lymphoma subtypes.
- Utilizing bcl-1, bcl-6, CD43, and morphological assessment is crucial for accurate diagnosis and differentiation.
- Recognition of these subtypes is essential for appropriate patient management and prognosis.
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