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[Cycloartane triterpenes and glycosides from Cimicifuga acerina]
1Department of Phytochemistry, China Pharmaceutical University, Nanjing 210009, China.
Aim:
To investigate the chemical constituents from the rhizomes of Cimicifuga acerina (Sieb. et Zucc.) Tanaka.
Methods:
Column chromatgraphy (including silica gel and ODS) together with HPLC was used to separate the chemical constituents whose structures were determined by FAB-MS, NMR (1D and 2D) and hydrolysis methods.
Results:
Five cycloartane triterpenoids were isolated and identified as: (22R)-22-hydroxycimigenol (I), (22R)-22-hydroxy-24-O-acetylhydroshengmanol 3-O-beta-D-xylopyranoside (II), dahurinol (III), 24-epi-24-O-acetyl-7,8-didehydroshengmanol 3-O-beta-D-xylopyranoside (IV), 25-O-acetyl-7,8-didehydrocimigenol 3-O-beta-D-xylopyranoside (V).
Conclusion:
Compound I is a new natural product, compound II is a new compound and compounds IV and V were isolated from this plant for the first time.