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[Triterpenoid saponins from Eclipta prostrata L].

Y P Zhao1, H F Tang, Y P Jiang

  • 1Department of Pharmacy, Fourth Military Medical University, Xi'an 710032, China.

Yao Xue Xue Bao = Acta Pharmaceutica Sinica
|February 13, 2003
PubMed
Summary

Two new triterpenoid saponins were identified in Eclipta prostrata L. (Chinese traditional medicine). Compounds 1 and 5 also demonstrated antifungal activity against Pyricularia oryzae mycelia.

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Area of Science:

  • Phytochemistry
  • Natural Products Chemistry
  • Medicinal Chemistry

Context:

  • Eclipta prostrata L. is a widely used herb in traditional Chinese medicine.
  • Triterpenoid saponins are a class of bioactive compounds with diverse pharmacological properties.
  • Understanding the chemical constituents of medicinal plants is crucial for drug discovery.

Purpose:

  • To isolate and characterize triterpenoid saponins from Eclipta prostrata L.
  • To elucidate the structures of novel saponin compounds.
  • To investigate the biological activity of isolated saponins.

Summary:

  • Two new triterpenoid saponins, eclalbasaponins XI (4) and XII (5), were isolated and structurally elucidated using advanced spectroscopic techniques (IR, MS, NMR).
  • The structures were determined to be 3-O-[beta-D-glucopyranosyl(1-->2)-beta-D-glucopyranosyl]-16 alpha-ethoxy-olean-12-ene-28-oic acid-28-O-beta-D-glucopyranoside and 3-O-[(2-O-sulfuryl-beta-D-glucopyranosyl) (1-->2)-beta-D-glucopyranosyl]-echinocystic acid-28-O-beta-D-glucopyranoside.

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  • Three known saponins (eclalbasaponins II, I, and III) were also identified.

    • Impact:

    • The discovery of new triterpenoid saponins expands the known chemical diversity of Eclipta prostrata.
    • Compounds 4 and 5 represent novel chemical entities with potential for further investigation.
    • Compounds 1 and 5 exhibited inhibitory effects on the morphological development of Pyricularia oryzae mycelia, suggesting potential antifungal applications.