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[Application of FAM networks in recommendation of mobile phase for RP-HPLC]
1Center for Instrumental Analysis, China Pharmaceutical University, Nanjing 210009, China.
Yao Xue Xue Bao = Acta Pharmaceutica Sinica
|February 13, 2003
Abstract
Aim:
To establish expert system to recommend solvent strength in RP-HPLC by using FAM (fuzzy associate memorizer) networks.
Methods:
Symbolic rules reflecting the quantitative relationship among molecular structure, capacity factors and solvent strength in RP-HPLC were extracted from trained radial basis function networks. Then FAM networks consisting of these rules were built to recommend mobile phase strength for RP-HPLC.
Results:
The validation results of the system by monocomponent and mutilcomponent drug samples were satisfied.
Conclusion:
The mobile phase recommendation system for RP-HPLC analysis of drugs showed reliable performance.