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A Novel Inhalation Mask System to Deliver High Concentrations of Nitric Oxide Gas in Spontaneously Breathing Subjects
Published on: May 4, 2021
Inhaled nitric oxide and pulmonary vasoreactivity
1Department of Anesthesia, University of Pennsylvania, Philadelphia, PA 19104, USA. maranda@mail.med.upenn.edu
Journal of Clinical Monitoring and Computing
|February 13, 2003
Summary
Inhaled nitric oxide (NO), a molecule found naturally and in pollutants, is a vital clinical tool. This review covers its chemistry, history, administration, and clinical uses, including side effects and withdrawal strategies.
Area of Science:
- Pulmonary Medicine
- Biochemistry
- Toxicology
Background:
- Nitric oxide (NO) is an endogenous molecule with significant physiological roles.
- NO is also present in environmental factors like air pollution and cigarette smoke.
- Understanding NO's properties is crucial for its therapeutic applications.
Purpose of the Study:
- To review the chemistry, history, and clinical applications of inhaled nitric oxide (NO).
- To detail the biosynthesis, pulmonary effects, and administration of inhaled NO.
- To discuss indications, side effects, and withdrawal phenomena associated with inhaled NO therapy.
Main Methods:
- Literature review of nitric oxide (NO) chemistry and history.
- Analysis of NO's effects on pulmonary vasoreactivity.
- Compilation of data on inhaled NO administration, clinical uses, and adverse events.
Main Results:
- Inhaled nitric oxide (NO) has evolved from its initial description to current clinical use.
- Key aspects include NO biosynthesis, pulmonary vasoreactivity modulation, and administration protocols.
- Emphasis is placed on managing NO withdrawal, particularly the 'rebound' effect, and potential drug interactions.
Conclusions:
- Inhaled nitric oxide (NO) is an established and valuable therapeutic agent.
- Further research is needed to optimize dosage, duration, and assess potential toxicity.
- Ongoing studies will refine the use of inhaled NO in clinical practice.
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