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Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts
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Emerging cancer-targeted therapies

Robert J Arceci1, Timothy P Cripe

  • 1Department of Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, 1650 Orleans Street, Room 2M51, Baltimore, Maryland 21231, USA. arcecro@jhmi.edu

Pediatric Clinics of North America
|February 13, 2003
PubMed

Insights

Molecular biology advancements promise targeted cancer therapies for children. This review explores new approaches, preparing healthcare professionals and patients for the future of pediatric oncology.

Area of Science:

  • Pediatric Oncology
  • Molecular Biology
  • Translational Research

Background:

  • Cancer treatment for children is evolving.
  • Molecular biology offers new therapeutic avenues.

Purpose of the Study:

  • Highlight promising molecularly targeted therapies for pediatric cancers.
  • Prepare stakeholders for future changes in pediatric oncology practice.

Main Methods:

  • Review of emerging molecular biology and translational research.
  • Analysis of potential impacts on pediatric cancer care.

Main Results:

  • Selective targeting of tumor cells is becoming feasible.
  • New therapies are expected to change treatment paradigms.

Conclusions:

  • Understanding underlying biology and hurdles is crucial.
  • Proactive preparation is needed for integrating novel therapies into pediatric oncology.

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