Related Experiment Video
Updated: Sep 27, 2026

A Protocol for Analyzing Hepatitis C Virus Replication
Published on: June 26, 2014
Hepatitis C virus phylogeny: a useful clinical tool
J Cristina1, S Mukomolov, R Colina
1Departamento de Técnicas Nucleares Aplicadas, Centro de Investigaciones Nucleares, Facultad de Ciencias, Universidad de la República, Iguá 4225, 11400 Montevideo, Uruguay. cristina@cin1.cin.edu.uy
Abstract:
In order to type 45 recent isolates of Hepatitis C virus (HCV) originating from four different geographic regions of the world, we performed phylogenetic analysis of a 192 nucleotides (nts) long sequence from the 5'non-coding region (5'-NCR) of the virus genome and compared them with 55 HCV isolates/strains of known type. The results of this study showed that phylogenetic studies can assign an HCV isolate to the correct type in 100% and to the correct subtype in 98%. A comparison ofthis method with other methods using commercial kits revealed that it is appropriate for clinical use and is cost effective.
Related Concept Videos
Hepatitis
Viral Hepatitis I: Introduction
Microbial Phylogeny
Evolutionary Relationships through Genome Comparisons
Retroviruses

