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Updated: Sep 27, 2026
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Published on: June 27, 2020
E2A-PBX1 fusion in adult acute lymphoblastic leukaemia: biological and clinical features
Robin Foa1, Antonella Vitale, Marco Mancini
1Dipartimento di Biotecnologie Cellulari ed Ematologia, University La Sapienza, Rome, Italy. rfoa@bce.uniroma1.it
Abstract:
Molecular and cytogenetic studies performed in 305 adult acute lymphoblastic leukaemia (ALL) patients enrolled in the gimema (Gruppo Italiano Malattie EMatologiche dell'Adulto) multicentric protocols identified an E2A-PBX1 fusion and/or t(1;19) in 10 patients (3.3%). All had common ALL, were mostly CyIg+ and were CD34/CD13/CD33-. Nine patients achieved a complete remission (CR); five patients showed a haematological relapse after 7 months (median). Four patients are alive in first CR with a median follow-up of 29 months; three patients are molecularly negative. This abnormality is frequently associated with early treatment failure. E2A-PBX1+ adult ALL should be considered for intensified treatment strategies and monitoring of minimal residual disease.
