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Related Experiment Videos

Low-dose atorvastatin therapy does not augment endothelial function in active hypercholesterolaemic males.

Melinda M Parnell1, Jaye P F Chin-Dusting, Jennifer Starr

  • 1Alfred Baker Medical Unit, Baker Medical Research Institute, Melbourne, Australia.

British Journal of Clinical Pharmacology
|February 13, 2003
PubMed
Summary

Atorvastatin therapy did not improve endothelial function in physically active men with hypercholesterolaemia (HC). This study found no significant difference compared to a control group, suggesting statins may not benefit endothelial function in this population.

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Area of Science:

  • Cardiovascular Research
  • Pharmacology
  • Exercise Physiology

Background:

  • Hypercholesterolaemia (HC) is associated with impaired endothelial function.
  • Statin therapy is known to improve endothelial function in sedentary individuals.
  • The effect of statins on endothelial function in physically active HC individuals remains unclear.

Purpose of the Study:

  • To investigate the impact of atorvastatin on endothelial function in physically active men with HC.
  • To compare endothelial function between HC men and a normolipidaemic control group.

Main Methods:

  • A randomized crossover design was used to assess endothelial function via forearm blood flow response to acetylcholine infusion.
  • Subjects received either atorvastatin or no therapy.

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  • Comparison was made with an active, normolipidaemic control group.

    • Main Results:

    • Atorvastatin effectively reduced total and LDL cholesterol levels.
    • No significant improvement in basal blood flow or endothelial function was observed with atorvastatin therapy.
    • No significant difference in endothelial function was found between the hypercholesterolaemic and control groups.

    Conclusions:

    • Statin therapy does not appear to augment endothelial function in hypercholesterolaemic patients who already have normal endothelial function.
    • Physical activity may play a role in maintaining endothelial function despite hypercholesterolaemia.