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Antimicrobial resistance of Staphylococcus aureus isolated from impetigo patients between 1994 and 2000
Setsuko Nishijim1, Shigeo Ohshima, Toshiaki Higashida
1Department of Dermatology and Bacterial Medicine Laboratories, Kansa Medical University, Kori Hospital, Neyagawa, Osaka, Japan. nishijim@kouri.kmu.ac.jp
Background:
The incidence of strains of Staphylococcus aureus resistant to the antimicrobial agents used in treating impetigo has been increasing.
Aim:
To determine the antimicrobial susceptibility of S. aureus in impetigo.
Methods:
We measured the antimicrobial susceptibility of Staphylococcus aureus isolated from impetigo patients between 1994 and 2000.
Results:
The MIC50 of gentamicin was always higher than that of other antimicrobial agents until 1999. In isolates obtained since 1996, the MIC90 of gentamicin was over 12.5 micro g/mL, which is markedly higher than that found for other skin infections (folliculitis, furuncles, paronychia, phlegmone, secondary infection of eczema, dermatitis, ulcer and decubitus). There were no strains of S. aureus resistant to vancomycin and fusidic acid. After 2000, we could find only one strain resistant to minocycline and ofloxacin.
Conclusion:
Clindamycin has shown excellent activity against most S. aureus isolates between 1994 and 2000. The incidence of methicillin-resistant S. aureus was always below 20%.
Insights
Antimicrobial resistance in Staphylococcus aureus causing impetigo is rising. Clindamycin demonstrated excellent activity against most strains studied, with methicillin-resistant Staphylococcus aureus (MRSA) incidence remaining below 20%.
Area of Science:
- Medical Microbiology
- Dermatology
- Infectious Diseases
Background:
- Increasing incidence of antimicrobial resistance in Staphylococcus aureus strains.
- Growing concern over treatment efficacy for impetigo.
Purpose of the Study:
- To determine the antimicrobial susceptibility patterns of Staphylococcus aureus in impetigo.
- Evaluate resistance trends over a defined period.
Main Methods:
- Antimicrobial susceptibility testing of Staphylococcus aureus isolates from impetigo patients.
- Data collection spanning from 1994 to 2000.
Main Results:
- Gentamicin showed increasing MIC50 and MIC90 values, exceeding levels seen in other skin infections.
- No resistance observed to vancomycin and fusidic acid.
- Limited resistance to minocycline and ofloxacin noted after 2000.
Conclusions:
- Clindamycin exhibited excellent activity against the majority of Staphylococcus aureus isolates.
- The incidence of methicillin-resistant Staphylococcus aureus (MRSA) remained consistently below 20% throughout the study period.