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Related Experiment Videos

Large cell acanthoma.

Darius R Mehregan1, Fasahat Hamzavi, Karl Brown

  • 1Pinkus Dermatopathology Laboratory, P.C. Monroe, MI, USA. Darmehregan@Pinkuslab.com

International Journal of Dermatology
|February 13, 2003
PubMed
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Large cell acanthoma, a skin lesion on sun-damaged skin, shares similarities with other conditions. Research suggests it may be a reaction pattern related to lentigo senilis.

Area of Science:

  • Dermatopathology
  • Oncology
  • Dermatology

Background:

  • Large cell acanthoma (LCA) is a skin lesion that can be clinically mistaken for other pigmented lesions.
  • Differentiating LCA from conditions like lentigo senilis or pigmented actinic keratosis can be challenging.

Purpose of the Study:

  • To compare the histological and immunohistochemical features of large cell acanthoma with actinic keratosis and lentigo senilis.
  • To determine the potential relationship between large cell acanthoma and lentigo senilis.

Main Methods:

  • Histological examination of 19 large cell acanthoma cases.
  • Immunohistochemical staining using HMB-45 for melanocytes and proliferating cell nuclear antigen (PCNA) for keratinocyte proliferation.
  • Comparison of findings with actinic keratosis and lentigo senilis.

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Main Results:

  • Large cell acanthoma exhibits epidermal keratinocytes with enlarged nuclei and minimal pleomorphism.
  • Both LCA and lentigo senilis showed increased melanocyte density (HMB-45 staining).
  • Actinic keratosis demonstrated a statistically significant increase in keratinocyte proliferation (PCNA staining).

Conclusions:

  • Large cell acanthoma shares immunohistochemical similarities with lentigo senilis, particularly in melanocyte density.
  • Based on clinical, histological, and immunohistochemical data, LCA may represent a reactive pattern.
  • Further investigation supports a potential relationship between large cell acanthoma and lentigo senilis.