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Related Experiment Videos

Cross-reactivity patterns to budesonide.

A D Ferguson1, R M Emerson, J S C English

  • 1Department of Dermatology, Royal Hallamshire Hospital, Sheffield, UK. adam@fergusona2.freeserve.co.uk

Contact Dermatitis
|February 13, 2003
PubMed
Summary
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Budesonide allergy in allergic contact dermatitis patients shows cross-reactivity with hydrocortisone and triamcinolone. Patch testing is unreliable for determining corticosteroid cross-reactivity patterns.

Area of Science:

  • Dermatology
  • Allergology
  • Pharmacology

Background:

  • Allergic contact dermatitis (ACD) to topical corticosteroids is a recognized clinical issue.
  • Budesonide is a standard European marker for corticosteroid allergy, but its cross-reactivity profile remains poorly understood.
  • Understanding cross-reactivity is crucial for managing corticosteroid-induced ACD.

Purpose of the Study:

  • To investigate the cross-reactivity patterns of budesonide with other corticosteroids in patients with known budesonide allergy.
  • To evaluate the reliability of patch testing for assessing corticosteroid cross-reactivity.

Main Methods:

  • Patch testing and intradermal testing were performed on twelve patients previously positive to budesonide.
  • A control group of six patients negative to budesonide on patch testing was included.

Related Experiment Videos

  • A range of corticosteroids were used for testing cross-reactivity.

    • Main Results:

    • Budesonide demonstrated cross-reactivity with hydrocortisone-21-sodium phosphate and triamcinolone acetonide.
    • Patients identified as budesonide-allergic should avoid hydrocortisone and triamcinolone.
    • Patch testing was found to be an inaccurate method for determining corticosteroid cross-reactivity.

    Conclusions:

    • Budesonide allergy necessitates avoidance of hydrocortisone and triamcinolone due to cross-reactivity.
    • Current patch testing methods may not accurately reflect corticosteroid cross-reactivity.
    • Further research is needed to establish reliable methods for assessing corticosteroid cross-reactivity in allergic contact dermatitis.