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Consanguinity as risk factor for cervical carcinoma.

¹UAE University, Al Ain, United Arab Emirates. s.denic@uaeu.ac.ae

Medical Hypotheses

|February 13, 2003

Summary

Consanguineous marriage increases human papillomavirus (HPV) risk and cervical carcinoma. This may be due to sexual aversion between related spouses, promoting extramarital relations. Further research is warranted.

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Area of Science:

Reproductive Health
Epidemiology
Social Biology

Background:

Cervical carcinoma is primarily caused by human papillomavirus (HPV).
Risk factors for HPV infection include multiple sexual partners and consanguineous marriages.
Consanguinity may lead to sexual aversion between spouses, increasing the likelihood of extramarital affairs.

Purpose of the Study:

To investigate the hypothesis that consanguinity is a risk factor for HPV infection and cervical carcinoma.
To explore the role of Westermarck's effect in developing sexual aversion within consanguineous marriages.

Main Methods:

The study proposes testing a hypothesis linking consanguinity to HPV and cervical carcinoma.
The methodology would involve assessing sexual behavior and HPV infection rates in consanguineous versus non-consanguineous populations.
Biological imprinting and Westermarck's effect are considered as potential mechanisms.

Main Results:

Women married to relatives show a higher likelihood of HPV infection and cervical carcinoma.
Consanguineous spouses may experience mild sexual antipathy due to early childhood imprinting (Westermarck's effect).
This antipathy can lead to sex avoidance and seeking sexual satisfaction outside the marriage.

Conclusions:

Consanguinity presents a significant risk factor for HPV infection and subsequent cervical carcinoma.
The Westermarck effect, extended to spouses in consanguineous families, may explain the increased risk through induced sexual aversion.
Given the global prevalence of consanguinity, this hypothesis requires rigorous testing.

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