Evolutionary aspects of protein structure and folding
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Updated: Sep 27, 2026

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules
Published on: July 25, 2013
Edward N Trifonov1, Igor N Berezovsky
1Genome Diversity Center, Institute of Evolution, University of Haifa, Haifa 31905, Israel. trofonov@research.haifa.ac.il
Abstract:
The traditional reconstruction of molecular events of the past based on sequence conservation becomes very vague beyond one to two billion years ago. There are certain molecular features, however, such as polymer flexibility and loop closure, that are conserved merely because of their physical nature. This allows one to penetrate the earliest stages of protein evolution.
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