Creatine kinase and troponin after myocardial preservation using HTK solution (Custoidol) for clinical heart...

Area of Science:

• Cardiology
• Transplant Surgery
• Biochemistry

Background:

• Myocardial preservation is critical during heart transplantation.
• The effectiveness of Bretschneider histidine-tryptophan-ketoglutarate (HTK) solution for cardiac preservation requires ongoing evaluation.
• Assessing biochemical markers post-transplant is essential for monitoring myocardial health.

Purpose of the Study:

• To evaluate the efficacy of Bretschneider histidine-tryptophan-ketoglutarate (HTK) solution for myocardial preservation in heart transplant recipients.
• To analyze the impact of ischemic time on post-operative cardiac enzyme levels.

Main Methods:

• Study involved heart transplant patients receiving myocardial preservation with HTK solution.
• Post-operative serum levels of creatine kinase (CK), CK-MB, and troponin I were measured.
• Patients were stratified based on ischemic time (> or = 4 hours vs. < 4 hours).

Main Results:

• Elevated post-operative creatine kinase (CK), CK-MB, and troponin I levels were observed in patients with ischemic times of 4 hours or longer.
• Despite the increase, these biochemical markers remained within acceptable clinical ranges for heart transplantation.
• The HTK solution demonstrated adequate myocardial protection even with extended ischemia.

Conclusions:

• Bretschneider histidine-tryptophan-ketoglutarate (HTK) solution provides effective myocardial preservation in clinical heart transplantation.
• While prolonged ischemia (> or = 4 hours) is associated with a moderate increase in cardiac biomarkers, it does not compromise clinical outcomes.
• HTK solution is a viable option for myocardial protection during heart transplantation, even under extended ischemic conditions.