Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Microcephaly with plate-like cortical calcification.

Sridhar Kalyanasundaram1, Sourabh Dutta, Anil Narang

  • 1Department of Pediatrics, Post Graduate Institute of Medical Education and Research, 160012, Chandigarh, India.

Brain & Development
|February 13, 2003
PubMed
Summary

A neonate presented with microcephaly and unique cortical calcifications, suggesting an early developmental insult. This case highlights potential links between embryonic insults, brain development, and calcification patterns in congenital malformations.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

International collaborations in neonatal and fetal medicine - Low-and-middle income countries have the patients and high-income countries have the technology: Consensus, conundrums and controversies.

Seminars in fetal & neonatal medicine·2026
Same author

Multidrug-Resistant, Potentially Pathogenic Bacteria in Mother's Milk, and Neonatal Oral and Rectal Swabs of Preterm Mother-Neonate Dyads.

Indian journal of microbiology·2025
Same author

Change in composition of blood after passing through circuit of automated device versus manual clinical method for neonatal exchange transfusions.

European journal of pediatrics·2025
Same author

Shorter or biomarker-guided antibiotic durations for common serious neonatal infections: a collection of non-inferiority meta-analyses.

EClinicalMedicine·2025
Same author

Diagnostic Accuracy of Pediatrician-performed Digital Retinal Imaging with 3nethra neo for ROP Screening: Authors' Reply.

Indian journal of pediatrics·2025
Same author

Intrapartum Antibiotic Exposure and Neonatal Sepsis.

Indian pediatrics·2025

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Pediatric Neurology

Background:

  • Congenital central nervous system malformations arise from disruptions during embryonic development.
  • The timing of an insult dictates the resulting malformation's presentation.

Observation:

  • A neonate exhibited microcephaly (abnormally small head).
  • Associated findings included plate-like cortical calcification.

Findings:

  • The observed malformations suggest an insult occurred around 11-12 weeks post-conception.
  • This insult likely arrested the brain's proliferative phase.
  • Secondary vasculopathy may have contributed to diffuse cortical calcification.

Implications:

Related Experiment Videos

  • This case provides insight into the pathogenesis of specific congenital brain malformations.
  • Understanding early developmental insults is crucial for diagnosing and managing such conditions.
  • Further research may elucidate the specific agents causing these developmental arrests and calcifications.