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Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion
Published on: May 26, 2022
[Clinical study of changes of urotensin II in patients with congestive heart failure]
Ping Zhong1, Zhi-liang Li, Hong-chao Wu
1Department of Cardiology, Zhujiang Hospital, First Military Medical University, Guangzhou 510282, China. zhongping1964@yahoo.com.cn
Objective:
To investigate the changes of plasma urotensinII (UII) levels in patients with congestive heart failure (CHF) of different severities and their clinical implications.
Methods:
Plasma UII was determined by radioimmunoassay in 45 patients with CHF and 20 healthies control subjects. In all the subjects, the left ventricular fraction (LVEF) and the ratio of E/A were measured by echocardiography.
Results:
The plasma UII level was significantly lowered in CHF patients in comparison with that in control subjects (1.41+/-1.09 pg/ml vs 4.35+/-1.22 pg/ml, P=0.000). A significant correlation of plasma UII level with LVEF (r=0.540, P=0.000) and the E/A ratio was observed (r=0.539, P=0.000), and the severity of CHF was shown to be inversely correlated with plasma UII levels in the patients (r=-0.656, P=0.000), which was elevated after treatment.
Conclusion:
UII might play a role in the pathophysiological process of CHF, and its plasma level may serve as an indicator of the severity of CHF.
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