Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Wounds and malignancy.

Jennifer T Trent1, Robert S Kirsner

  • 1Department of Dermatology and Cutaneous Surgery, University of Miami School of Medicine, FL, USA.

Advances in Skin & Wound Care
|February 13, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Management of Diabetic Wounds: Expert Panel Consensus Statement.

Advances in wound care·2025
Same author

Patient Race and Ethnicity Do Not Predict Ulceration Among Ambulatory Patients With Venous Insufficiency.

Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society·2025
Same author

Evaluation of c-Myc and Phosphorylated Glucocorticoid Receptor (p-GR) for Predicting Diabetic Foot Ulcer Healing-A Diabetic Foot Consortium Study.

Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society·2025
Same author

Melanoma Incidence and Survival: A SEER Database Study.

The Journal of investigative dermatology·2025
Same author

Merkel Cell Carcinoma and Pruritus: A Retrospective Cohort Study.

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]·2025
Same author

Prevalence and Mechanisms of Itch in Chronic Wounds: A Narrative Review.

Journal of clinical medicine·2025
Same journal

Validity and Reliability of Barakat-Johnson Incontinence-Associated Dermatitis Knowledge Tool: A Methodological Study.

Advances in skin & wound care·2026
Same journal

Predicting Risk Factors of Pressure Injury for Perioperative Patients Through Machine Learning With SHapley Additive exPlanations Based on Hospital Information System.

Advances in skin & wound care·2026
Same journal

A Retrospective Analysis of Deep Tissue Pressure Injury Prevalence and Incidence Using a Large-scale Wound Care Database in Long-term Care Settings Across North America.

Advances in skin & wound care·2026
Same journal

Malnutrition in Older Adults With Chronic Wounds: A Prospective Cohort Study.

Advances in skin & wound care·2026
Same journal

Effect of Hydrocolloid Dressing and Terpolymer-Based Alcohol-Free Barrier Film on Pain During Tape Removal in Nasogastric Tube Fixation in Infants: A Randomized Controlled Trial.

Advances in skin & wound care·2026
Same journal

Novel Surgical Approach for Wound Closure of Large Livedoid Vasculopathy Wounds: A Case Series.

Advances in skin & wound care·2026
See all related articles

Healthcare providers managing wounds may encounter skin cancers. This review covers malignant changes in chronic wounds and cancers presenting as wounds, focusing on squamous cell carcinoma development.

Area of Science:

  • Dermatology
  • Oncology
  • Wound Care

Background:

  • Skin cancers are prevalent, impacting wound management practices.
  • Chronic wounds and malignancies can be interrelated in two primary ways: malignant transformation of chronic wounds and malignancies presenting as chronic wounds.
  • Squamous cell carcinoma (SCC) is commonly associated with chronic wounds, particularly those linked to chronic osteomyelitis.

Purpose of the Study:

  • To review the relationship between malignancies and chronic wounds.
  • To discuss the challenges in differentiating malignant transformation from primary malignant ulcers.
  • To outline diagnostic and treatment considerations for these conditions.

Main Methods:

  • Literature review focusing on the association between chronic wounds and cutaneous malignancies.

Related Experiment Videos

  • Analysis of clinical scenarios involving malignant degeneration of wounds and malignancies presenting as wounds.
  • Examination of diagnostic criteria and treatment modalities.

    • Main Results:

    • Chronic wounds from various causes (osteomyelitis, burns, trauma, radiotherapy, diabetes) carry a risk of malignant degeneration.
    • Distinguishing malignant transformation from primary malignant ulcers can be challenging.
    • Biopsy is recommended for suspicious wounds; primary malignancy should be considered for ulcers with short duration and no prior radiotherapy history.

    Conclusions:

    • Healthcare practitioners must be aware of the potential for malignant changes in chronic wounds.
    • Early recognition and biopsy of suspicious wounds are crucial for accurate diagnosis.
    • While amputation was a traditional treatment for SCC in chronic wounds, complete local excision is increasingly recognized as effective.