Conjunctival provocation testing: overview of recent clinical trials in ocular allergy

The conjunctival provocation test is a human model of ocular allergy that has been used to study the ocular response to allergenic stimuli and to evaluate antiallergic therapy. The review will discuss recent studies using the conjunctival provocation test and other models of ocular allergy, and evaluate the relative merits of different models.

The conjunctival provocation test has allowed investigators to recruit large numbers of allergic individuals who, although asymptomatic, can be challenged with the conjunctival administration of allergen. Observations of the eye can be made before and after challenge, and cells and mediators may be sampled from the ocular surface. In addition, the effectiveness of antiallergic therapy can be evaluated, usually by pretreating the two eyes with different forms or doses of drug.

Considerable useful information has been gained about the ocular allergic response and drug efficacy using the conjunctival provocation test and naturally occurring seasonal allergic conjunctivitis.