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[Apoptotic morphological changes and TUNEL of human gastric cancer cell SGC-7901 induced by aining]
Miancheng Su1, Mei Dai, Xiaoying Lü
1National Engineering Research Center for Mordernization of TCM, Zhuhai 519020.
Objective:
To investigate the inducing apoptosis effect of Aining on the human gastric cancer cell SGC-7901.
Methods:
In vitro cell culture was adopted to explore the inducing apoptosis effect of Aining and cisplation (DDP) through the morphological method and the molecular method.
Results:
Apoptotic morphological changes were seen after the cells cultured with Aining or DDP; apoptosis rate of 1 g/L Aining group was 46.36%, which had no significant differences with the apoptosis rate 49.12% of the 25 mg/L DDP group; both of the Aining and the DDP groups were significantly different from that of the blank group(P < 0.01).
Conclusions:
Both DDP and Aining could induce the apoptosis of human gastric cancer cell and the traditional medicine compound prescription Aining is likely to become a new agent which is used to induce apoptosis of cancer cells.
Insights
Aining, a traditional Chinese medicine, effectively induces apoptosis in human gastric cancer cells, similar to cisplatin. This suggests Aining
Area of Science:
- Oncology
- Cell Biology
- Pharmacology
Context:
- Gastric cancer remains a significant global health challenge.
- Current treatments like cisplatin (DDP) can have severe side effects.
- Novel therapeutic agents are needed to improve gastric cancer treatment outcomes.
Purpose:
- To evaluate the apoptosis-inducing effects of Aining on human gastric cancer cells (SGC-7901).
- To compare the efficacy of Aining with cisplatin (DDP) in inducing cancer cell apoptosis.
- To explore Aining's potential as a novel anti-cancer therapeutic.
Summary:
- In vitro studies demonstrated that Aining induced significant apoptotic morphological changes in SGC-7901 cells.
- The apoptosis rate in the Aining group (46.36%) was comparable to the cisplatin group (49.12%).
- Both Aining and DDP significantly increased apoptosis compared to the control group (P < 0.01).
Impact:
- Aining exhibits potent apoptosis-inducing capabilities in human gastric cancer cells.
- Aining shows comparable efficacy to cisplatin, suggesting its potential as a less toxic alternative.
- This research highlights Aining as a promising candidate for developing new gastric cancer therapies.
