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Updated: Sep 13, 2026
An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause
Published on: August 13, 2019
[Hypocholesterolemic effect of total isoflavones from Pueraria lobata in ovariectomized rats]
Gaoli Zheng1, Xinyue Zhang, Jingwei Zheng
1Institute of Metaria Medica, Zhejiang Academy of Medical Sciences, Hangzhou 310013.
Objective:
To observe the effects of total isoflavones from Pueraria lobata (TIP) on lipid metabolism in estrogen deficient rat.
Methods:
Female SD rats were bilaterally ovariectomized under anesthesia. TIP was administrated orally for 7 months. Serum lipids were determined at 1.5, 4.0 and 7.0 months, and liver lipids were detected at 7 months.
Results:
Compared with non-ovariectomized rats, serum TC level and the ration of TC/HDL-C in ovariectomized rats were obviously increased while HLD-C was slightly induced and TG level were changeless. In TIP-treated groups, serum TC level and the ratios of TC/HDL-C were markedly lowered than those in OVX group, while HDL-C slightly increased. TG level were much reduced in 1.5 month and changeless in 4.0 and 7.0 month. Slightly increase of cholesterol and markedly induction of triglyceride tissue were observed in liver.
Conclusion:
TIP significantly decreased concentrations of serum TC and liver TG in OVX rats.
