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The Dimethylnitrosamine Induced Liver Fibrosis Model in the Rat
Published on: June 17, 2016
[Effect of tanshinone IIA on CCl4-induced liver fibrosis in rats]
Yonggang Liu1, Houchang Chen, Yiping Jiang
1First Military Medical University, Guangzhou 510515.
Objective:
To study the effect of tanshinone IIA on liver fibrosis in rats induced by CCl4.
Methods:
Model of liver fibrosis in rats were induced by subcutaneous injection of CCl4 and malotilate was as positive control. The histological changes were observed with light microscope. The levels of ALT, AST, NO, HA, LN in serum and Hyp, MDA in liver tissue were determined to reveal the event liver damage.
Result:
Tanshinone IIA could significantly reduce the elevate levels of ALT, AST, NO, HA, LN in serum and Hyp, MDA in liver tissue. Pathological examination suggested tanshinone IIA has therapecuical effect on experimental liver fibrosis.
Conclusion:
Tanshinone IIA may have therapeutical effect on CCL4-induced liver fibrosis in rats.
