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Mono- versus bidentate ligands in rhodium-catalyzed asymmetric hydrogenation. A comparative rate study
Diego Peña1, Adriaan J Minnaard, André H M de Vries
1Department of Organic and Molecular Inorganic Chemistry, Stratingh Institute, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands.
Organic Letters
|February 14, 2003
Abstract:
[reaction: see text] Bidentate chiral phosphines are no longer essential for achieving a fast and highly enantioselective hydrogenation of alpha- or beta-dehydroamino acid derivatives. In particular, a readily accessible and stable monodentate phosphoramidite can be highly effective in these asymmetric hydrogenations.