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First direct reductive amination of mucochloric acid: a simple and efficient method for preparing highly
Ji Zhang1, Peter G Blazecka, James G Davidson
1Chemical Research and Development, Pfizer Global Research & Development, Ann Arbor Laboratories, Pfizer, Inc., 2800 Plymouth Road, Ann Arbor, Michigan 48105, USA. ji.zhang@pfizer.com
Organic Letters
|February 14, 2003
Abstract:
[reaction: see text] The first direct reductive amination of mucochloric acid (1) has been accomplished. Reaction of 1 with various alkyl, aryl, and benzylamines, followed by reduction in the same pot, provides an efficient method of obtaining N-benzyl-3,4-dichloro-1,5-dihydro-pyrrol-2-one and N-aryl (or alkyl)-3,4-dichloro-1,5-dihydro-pyrrol-2-ones.