Related Experiment Videos
Tubulin interacting agents: novel taxanes and epothilones
Neeraj R Agrawal1, Ram Ganapathi, Tarek Mekhail
1Experimental Therapeutics, Taussig Cancer Center, The Cleveland Clinic Foundation, R35, 9500 Euclid Avenue, Cleveland, OH 44195, USA. Mekhait@ccf.org
Current Oncology Reports
|February 14, 2003
Abstract:
The microtubule cytoskeleton plays an important part in cell mitosis, which relies on polymerization and depolymerization of the protein tubulin. Such established drugs as the vinca alkaloids and colchacine work by inhibiting microtubule assembly, as does paclitaxel. This article describes a variety of promising novel taxanes and epothilones with similar mechanisms of action that are in various states of preclinical and clinical development.