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Mumps virus decreases testosterone production and gamma interferon-induced protein 10 secretion by human leydig cells
Ronan Le Goffic1, Thomas Mouchel, Annick Ruffault
1INSERM U 435/GERM, Université de Rennes I, Campus de Beaulieu, 35042 Rennes, France.
Journal of Virology
|February 14, 2003
Abstract:
Mumps virus is responsible for sterility. Here, we show that the mumps virus infects Leydig cells in vitro and totally inhibits testosterone secretion and that ribavirin in mumps virus-infected Leydig cell cultures completely restores testosterone production. Moreover, we show that gamma interferon-induced protein 10 (IP-10) is highly expressed by mumps virus-infected Leydig cells and that ribavirin does not block IP-10 production.