Neuroimmunomodulation and immune privilege: the role of neuropeptides in ocular immunosuppression
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Updated: Sep 27, 2026

Induction of Ocular Surface Inflammation and Collection of Involved Tissues
Published on: August 4, 2022
1Department of Ophthalmology, Harvard Medical School, Boston, Massachussetts 02114, USA. awtaylor@vision.eri.harvard.edu
Abstract:
Regional immunoregulatory mechanisms insure that the most effective immune defense mounted is in proportion with preserving unique tissue functionalities. Immune-privileged tissues, such as the eye, are tissue sites of extreme regional immunoregulation. They have evolutionarily adapted several mechanisms to prevent the induction of inflammation within their tissue microenvironment. With over half a century of experimental examinations of ocular immune privilege, only recently have we come to understand that neuropeptides constitutively present in ocular tissues are part of the mechanisms of immune privilege.
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