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Updated: Sep 27, 2026

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography
08:13

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography

Published on: February 16, 2016

[Comparison of an edema-sensitive HASTE-TIRM sequence with delayed contrast enhancement in acute myocardial infarcts]

A Stork1, G K Lund, M Bansmann

  • 1Klinik und Poliklinik für Diagnostische und Interventionelle Radiologie, Universitätsklinikum Eppendorff, Hamburg. astork@uke.uni-hamburg.de

Rofo : Fortschritte Auf Dem Gebiete Der Rontgenstrahlen Und Der Nuklearmedizin
|February 14, 2003
PubMed
Abstract

Insights

Fluid-sensitive HASTE-TIRM MRI sequences detect more myocardial infarct edema than contrast-enhanced MRI. This sequence may identify viable but impaired heart muscle after acute myocardial infarction (AMI).

Area of Science:

  • Cardiovascular Imaging
  • Magnetic Resonance Imaging
  • Myocardial Infarction Assessment

Background:

  • Acute myocardial infarction (AMI) diagnosis and assessment are crucial for patient outcomes.
  • Magnetic Resonance Imaging (MRI) is a key modality for evaluating cardiac damage.
  • Differentiating infarct core from peri-infarct tissue is essential for treatment decisions.

Purpose of the Study:

  • To compare the efficacy of a fluid-sensitive HASTE-TIRM sequence with delayed contrast-enhancement (CE) MRI in patients with AMI.
  • To assess the ability of these sequences to delineate infarct size and transmurality.
  • To investigate the potential of HASTE-TIRM to identify viable but functionally impaired myocardium.

Main Methods:

  • 32 patients with AMI underwent MRI 7 days post-infarction using a 1.5 T unit.
  • Imaging included T2 HASTE-TIRM and contrast-enhanced T1 turbo FLASH sequences.
  • Hyperintense zones were quantified using a threshold method (>2 SD above normal myocardium), and transmurality was measured segmentally.

Main Results:

  • HASTE-TIRM identified significantly larger hyperintense areas (29.6% of LV) compared to CE-MRI (19.2% of LV) (p < 0.0001).
  • Higher transmurality of hyperintense regions was observed with HASTE-TIRM versus CE-MRI (p < 0.0001).
  • CE-MRI correlated well with peak creatine kinase (CK max) (r=0.59), while HASTE-TIRM did not (r=0.29).

Conclusions:

  • The HASTE-TIRM sequence effectively depicts peri-infarct edema in addition to the non-viable infarct zone.
  • HASTE-TIRM demonstrates greater transmurality of hyperintense regions compared to CE-MRI.
  • The additional area identified by HASTE-TIRM may represent functionally impaired but viable myocardium, offering prognostic value.

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