Related Experiment Video
Updated: Sep 27, 2026
Mouse Electroacupuncture Fixation Device Fabrication for Electroacupuncture Pretreatment in Diabetic Cardiomyopathy Mouse Model
Published on: April 18, 2025
[Effect of shengmai injection on hemodynamics in patients with dilated cardiomyopathy]
Ya-chen Zhang1, Rui-ming Chen, Mei-hua Zhao
1Department of Cardiovascular Diseases, Xinhua Hospital Affiliated to Shanghai Second Medical University, Shanghai 200092.
Insights
Shengmai Injection (SMI) significantly improved heart function and hemodynamics in patients with dilated cardiomyopathy (DCM). Combining SMI with conventional treatment enhanced therapeutic effects for heart failure in DCM patients.
Area of Science:
- Cardiology
- Pharmacology
Background:
- Dilated cardiomyopathy (DCM) is a significant cause of heart failure.
- Hemodynamic dysfunction is a hallmark of DCM, leading to poor prognosis.
Purpose of the Study:
- To evaluate the hemodynamic effects of Shengmai Injection (SMI) in DCM patients.
- To assess the clinical efficacy of SMI in treating DCM with co-existing heart failure.
Main Methods:
- A randomized controlled trial involving 100 DCM patients.
- Patients were divided into a control group (conventional treatment) and a treated group (conventional treatment + SMI).
- Hemodynamic parameters and heart function indexes were measured before and after treatment.
Main Results:
- The treated group showed a significantly higher total effective rate (84%) compared to the control group (60%).
- SMI administration led to significant improvements in cardiac output, stroke volume (SV), cardiac index, ejection fraction (EF), and left ventricular remodeling indices.
- Systemic vascular resistance (SVR) significantly decreased in the SMI-treated group.
Conclusions:
- Shengmai Injection demonstrates a marked ability to improve cardiac function in DCM patients.
- Combination therapy with SMI enhances the effectiveness of conventional treatments for DCM-related heart failure.
Objective:
To observe the effects of Shengmai Injection (SMI) on hemodynamics in patients with dilated cardiomyopathy (DCM), and to explore the clinical effect of SMI in treating patients of DCM with heart failure.
Methods:
One hundred patients were divided into two groups. In the 50 cases of the treated group, 10 cases with heart function of II degree, 35 of III degree and 5 of IV degree. The corresponding number of cases in the 50 patients of the control group were 10, 36 and 4. Conventional treatment was given to both groups, and SMI was administered to the treated group additionally. The therapeutic effect and the indexes of heart function before and after treatment were determined and compared.
Results:
In the treated group, treatment showed markedly effective in 22 cases and effective in 20, the total effective rate being 84%, while in the control group, markedly effective in 14 and effective in 16, the total effective rate being 60%, the comparison between the two groups showed significant difference (chi 2 = 7.14, P < 0.01). In the treated group, cardiac output, stroke volume (SV), cardiac index, eject fraction (EF), lefe ventricular minor axis shortened rate, ventricular wall thickened rate were all increased after treatment and system vascular resistance (SVR) decreased significantly (P < 0.05), while in the control group, insignificant change was found in the above-mentioned parameters after treatment (P > 0.05). Comparison between the two groups after treatment showed that EF and SV were obviously higher and SVR obviously lower in the treated group than those in the control group.
Conclusion:
SMI could markedly improve the heart function of patients with DCM. The effect of conventional treatment would be enhanced in combination therapy with SMI.
Related Concept Videos
01:26Heart Failure Drugs: Inotropic Agents
01:26Heart Failure Drugs: Inhibitors of Renin-Angiotensin System