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[Study on preventive effect of jiangu granule on osteoporosis in ovariectomized rats]
Yan-ping Lin1, Jian-hua Ma, Er-you Feng
1Faculty of Orthopedics and Traumatology, Fujian College of TCM, Fuzhou 350003.
Objective:
To investigate the preventive effect of Jiangu granule (JGG) on experimental primary osteoporosis type I.
Methods:
Osteoporosis model was established through ovary resection of female rats. Bone mineral density (BMD) was measured with double energy X-ray absorptiometry. Level of endocrine markers, including osteocalcin (BGP), estradiol (E2) and calcitonin (CT) in serum were examined by RIA. And uterus parameters was calculated also.
Results:
JGG could significantly increase BMD and uterus index, improve the levels of E2 and CT in serum, at the same time reduce the BGP level.
Conclusion:
JGG can efficiently prevent type I primary osteoporosis or delay its occurrence by enhancing the function of endocrine system, coordinating the action of calcium related hormone, reducing bone turnover rate and increasing BMD.