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[Study on the metabolism of psuedo-ginsenoside F11 in rats]
Aim:
To study the metabolic pathways of psuedo-ginsenoside F11 in rats.
Methods:
By use of the prep-TLC, the metabolites were isolated.
Results:
From the feces, three metabolites, psuedo-ginsenoside-RT5, ocotillol, and a new compound, F-3-1 (44) were isolated and identified by means of NMR evidence. But, such metabolites were found from neither the bile nor the urine of the rat. F-3-1 was identified as 6-O-alpha-L-rhamnopyranosyl-(1-2)-beta-D-glucopyranosyl-(20S,23S,24R)- dammar-20(24)-epoxy-3 beta, 6 alpha, 12 beta, 23,25-pentanol.
Conclusion:
Psuedo-ginsenoside-F11 can not be metabolized in the rat liver, but can be metabolized in the large intestine of the rat.