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[Effect of Panax notoginseng saponins on human kidney fibroblast]
Ying Wei1, Jun-ming Fan, Li-ping Pan
1Red-Cross Hospital of Yunnan, Kunming 650021.
Objective:
To study the effect of Panax notoginseng saponins (PNS) on cell proliferation, type I collagen secretion and integrin beta 1 expression in human kidney fibroblast (KFB).
Methods:
KFB were cultured and stimulated by PNS in vitro. The cell proliferation, type I collagen secretion and integrin beta 1 expression in KFB were measured by methyl thiazolyl tetrazolium (MTT), enzyme-linked immunoabsorbent assay (ELISA) and flowcytometry respectively.
Results:
Within its optimal concentration range and effective time range, PNS could obviously inhibit the proliferation, type I collagen secretion and integrin beta 1 expression (all P < 0.05) in human KFB.
Conclusion:
PNS would possibly be an effective drug for renal interstitial fibrosis prevention and treatment.
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