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[Effect of shenmai injection on diaphragmatic fatigue in children with respiratory failure]

Chun-xue Yan1, Yun-gang Yang, Zheng-xia Zhang

  • 1Yuying Children Hospital, Wenzhou Medical College, Zhejiang 325000.

Zhongguo Zhong Xi Yi Jie He Za Zhi Zhongguo Zhongxiyi Jiehe Zazhi = Chinese Journal of Integrated Traditional and Western Medicine
|February 15, 2003
PubMed

Insights

Shenmai injection (SMI) effectively treats diaphragmatic fatigue in pediatric respiratory failure. SMI improved patient outcomes and reduced fatigue duration compared to standard care, showing its clinical value.

Area of Science:

  • Pediatric Critical Care
  • Respiratory Medicine
  • Pharmacology

Background:

  • Diaphragmatic fatigue is a significant complication in pediatric respiratory failure.
  • Effective treatments for diaphragmatic fatigue in children are crucial for improving outcomes.

Purpose of the Study:

  • To evaluate the efficacy of Shenmai injection (SMI) in treating diaphragmatic fatigue in pediatric patients with respiratory failure.

Main Methods:

  • A comparative study involving 35 children with respiratory failure and diaphragmatic fatigue.
  • Patients were divided into a control group (comprehensive therapy) and an SMI group (SMI plus comprehensive therapy).
  • Electrical impedance respirogram (IRG) and arterial blood gas analysis were used to assess therapeutic effects.

Main Results:

  • SMI demonstrated a significantly higher effective rate (15/18) within 30 minutes compared to the control group (4/17).
  • The SMI group showed a more significant decrease in PaCO2 and a shorter time for diaphragmatic fatigue disappearance.
  • Treatment led to increased blood pH and decreased PaCO2 in both groups, with greater improvement in the SMI group.

Conclusions:

  • Shenmai injection is an effective treatment for diaphragmatic fatigue in children with respiratory failure.
  • SMI offers a favorable safety profile and is recommended for clinical application.
  • The study highlights SMI's potential to improve respiratory support and patient recovery.
Abstract

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