Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Transmissible spongiform encephalopathies in humans].

C Rogivue1, J Gottwein, A Aguzzi

  • 1Bundesamt für Gesundheit, Bern. colette.rogivue@bluewin.ch

Schweizer Archiv Fur Tierheilkunde
|February 15, 2003
PubMed
Summary

Transmissible spongiform encephalopathies (TSEs) are untreatable human brain diseases. Switzerland has seen no variant CJD cases despite BSE exposure, but an unexplained rise in sporadic CJD since 2001.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[The unusual mimicker of a polymyositis].

Zeitschrift fur Rheumatologie·2022
Same author

Analysis of co-isogenic prion protein deficient mice reveals behavioral deficits, learning impairment, and enhanced hippocampal excitability.

BMC biology·2022
Same author

Typing of inflammatory lesions of the pituitary.

Pituitary·2021
Same author

[COVID-19 and the central and peripheral nervous system].

Der Pathologe·2021
Same author

Common disbalance in the brain parenchyma of dementias: Phospholipid profile analysis between CADASIL and sporadic Alzheimer's disease.

Biochimica et biophysica acta. Molecular basis of disease·2020
Same author

Plasma total prion protein as a potential biomarker for neurodegenerative dementia: diagnostic accuracy in the spectrum of prion diseases.

Neuropathology and applied neurobiology·2019

Area of Science:

  • Neurology
  • Prion Diseases
  • Epidemiology

Context:

  • Human transmissible spongiform encephalopathies (TSEs) are progressive, fatal neurodegenerative disorders.
  • Sporadic Creutzfeldt-Jakob disease (sCJD) is the most common form, with familial (fCJD) and iatrogenic (iCJD) subtypes.
  • A variant form (vCJD) emerged in 1996, linked to Bovine Spongiform Encephalopathy (BSE) prions.

Purpose:

  • To review the landscape of human TSEs, including Creutzfeldt-Jakob disease (CJD) subtypes.
  • To discuss the epidemiological situation in Switzerland, particularly regarding BSE exposure and sCJD trends.
  • To highlight the importance of preventive measures given the current untreatable nature of TSEs.

Summary:

  • Human TSEs, including various forms of CJD, are untreatable dementing diseases.

Related Experiment Videos

  • Biochemical and neuropathological differences distinguish vCJD from sCJD, suggesting vCJD arises from BSE prion transmission.
  • Switzerland has not reported vCJD cases despite BSE exposure, but has observed an unexplained increase in sCJD since 2001.

    • Impact:

    • Understanding the distinct characteristics of CJD subtypes is crucial for diagnosis and surveillance.
    • The findings underscore the need for continued monitoring and stringent preventive strategies against prion diseases.
    • The unexplained rise in sCJD warrants further investigation into potential environmental or epidemiological factors in Switzerland.