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Esophageal function in progressive systemic sclerosis.

G J Krejs, M M Lobsiger, R Rau

    Acta Hepato-Gastroenterologica
    |February 1, 1976
    PubMed
    Summary
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    Systemic progressive sclerosis (PSS) frequently causes esophageal dysfunction, impacting peristalsis and lower esophageal sphincter pressure, leading to delayed clearance. Esophageal damage can occur even without noticeable symptoms.

    Area of Science:

    • Gastroenterology
    • Rheumatology
    • Clinical Medicine

    Background:

    • Systemic progressive sclerosis (PSS) is a multisystem autoimmune disease.
    • Esophageal involvement is common in PSS, affecting motility and potentially leading to complications.

    Purpose of the Study:

    • To investigate the spectrum and early detection of esophageal dysfunction in patients with systemic progressive sclerosis.
    • To evaluate diagnostic methods for esophageal involvement in PSS.

    Main Methods:

    • Prospective study of 13 consecutive patients diagnosed with systemic progressive sclerosis (PSS).
    • Utilized cineradiography, manometry, and esophageal suction biopsy for diagnosis.
    • Assessed esophageal peristalsis, lower esophageal sphincter (LES) pressure, and LES relaxation.

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    Main Results:

    • 12 out of 13 patients exhibited mild to severe esophageal involvement.
    • Esophageal dysfunction, including impaired peristalsis, can manifest early in PSS.
    • Lower esophageal sphincter (LES) incompetence typically appears 7-8 years after disease onset.
    • Delayed esophageal clearance is linked to impaired peristalsis and LES pressure.
    • Esophageal suction biopsy diagnoses esophagitis but not scleroderma itself.
    • Significant esophageal damage and gastroesophageal reflux may be asymptomatic.

    Conclusions:

    • Esophageal involvement is highly prevalent in systemic progressive sclerosis (PSS).
    • Cineradiography and manometry are effective tools for diagnosing esophageal motility disorders in PSS.
    • Early detection and management of esophageal dysfunction are crucial, as symptoms may not correlate with disease severity.